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Inverted Microsciopes

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Inverted microscope is a type of microscope designed to observe living cells or organisms settled at the bottom of a large container such as tissue culture flask. In such design of a microscope, the light source and condenser are fixed at the top, above the stage whereas the objectives and turret are placed below the stage pointing in upward direction. It was invented in 1850 by J. Lawrence Smith, a faculty member of Tulane.

Besides useful in examining living cells at the bottom of containers, inverted microscopes are also designed for micromanipulation applications where space above the sample is desirable for ensuring mechanisms of manipulation.